Job Description

Associate Director/Director Program Management Office




Why Join Us?

Be a hero for our rare disease patients

At Ultragenyx, we fundamentally believe that taking real impactful action to care for the needs of patients and our people is always the right thing to do. To achieve this goal, our vision is to lead the future of rare disease medicine. For us, this means going where other biopharma companies won’t go challenging the status quo and creating a new model that advances our field so more patients and caregivers can benefit from life-changing treatments. We do this by following the science, applying a novel rapid development approach, making innovative medicines at fair and reasonable prices, and creating a collaborative ecosystem to reach patients in ways that are most meaningful for them.

Our commitment and care for patients extends to our people, so culture is an essential cornerstone for Ultragenyx. We remain continuously focused on creating a supportive and inclusive environment of profound learning and growth so employees can thrive in all areas of their lives, in and outside of work. Ultimately, we want to be an organization where we would be proud for our family, friends and children to work.

If you want to have a meaningful impact, do the best work of your career, and grow a lot, both professionally and personally, come join our team. During the COVID-19 pandemic, we are committed to the health and safety of our employees and prospective employees, which means at this time our interview processes may include virtual discussions, interviews, and onboarding. Please note that compliance with local regulations and safety protocols is a condition of employment at Ultragenyx. Elements of safety protocols may include, but are not limited to: work from home requirements, regular or symptom-based covid testing, providing valid evidence of vaccination, mask wearing, and physical distancing.

US based roles: Full vaccination against COVID-19 is a condition of employment at Ultragenyx. This requirement applies to almost all roles at Ultragenyx based in the U.S., with very limited exceptions. If you are unable to receive a COVID-19 vaccine due to a disability, serious medical condition, or because it would violate your sincerely held religious belief, you will have an opportunity to request a reasonable accommodation.

Roles based outside the US: If the role requires travel to the US or another country that requires evidence of covid vaccination for entry, candidates and employees will be required follow the local regulations and corporate policy regarding vaccination evidence submission.

Position Summary:

Ultragenyx is looking for an Associate Director/Director with a passion and creativity to develop great medicines for rare and ultra-rare diseases. The individual will be a self-starter with excellent project management skills and the ability to build strong rapport across functions. The successful candidate will be ready for a career defining experience and have the passion to drive a number of therapeutics for devastating diseases to final approval and launch.

This position will report to the Vice President or other senior leader of Program and Portfolio Management and will be responsible for managing one or more programs depending on the stage and scope of a program within translational research through commercialization stages. In addition, this individual will actively support development of the department and tools/process across the portfolio.

Work Model:

Remote: officially documented as working full time from home, with travel to Ultragenyx’s offices or other location on occasion as needed


  • Support the program team to develop, maintain and execute the integrated translational research, development strategy, CMC, medical affairs, and/or commercial strategy for multiple programs (both small molecules and/or biologics). The number of programs will depend on stage and scope of the programs.
  • Directs and controls multiple programs that are cross-functional translational research, development, CMC, medical affairs, and/or commercial teams, through translational research, development and commercialization.
  • Design, develop and manage project schedules for Translational Research projects, Business Development candidate projects, Clinical, and/or Commercial-stage programs.
  • Lead and develops the cross-functional plans together including realistic but aggressive timelines, budget and resources planning, risk assessment and contingency planning.
  • Ensures cross-functional alignment and organizational support for the execution of the program plan by facilitating internal and external stakeholder meetings. Driving the team to out-of-box thinking and creative issue resolution.
  • Lead and drives objective setting process for programs.
  • Responsible for monitoring and tracking the project against approved timelines and milestones, and ensures adherence to agreed-upon team objectives and deliverables.
  • Manages prioritization of project team activities to enhance program value.
  • Acts as spokesperson for the program, and may represent program internally and externally.
  • Responsible for comprehensiveness and quality of program information in the internal systems, databases, and communication to Senior Management and program team
  • Expected to identify bottlenecks, surface issues, and proactively drive for their resolution. Leads contingency planning efforts.
  • Conducts thorough assessment of intangible variables, fundamental issues, providing strategy and directions for multiple programs and/or initiatives
  • Leads ad-hoc cross-functional task forces as needed aiming at issue resolution.
  • Consistently works with abstract ideas or situations across functional areas
  • Ensures effective, proactive and open communications, horizontally and vertically, in order to achieve transparency and clarity of program goals, progress and issues.
  • Develop departmental processes, procedures and tools to improve departmental functioning and portfolio management.
  • Supports/leads/drives corporate policies and process improvements, and ensures consistent implementation.
  • May be supervising PCs/PMs/Sr PMs
  • Managing a portfolio of programs and/or initiatives


  • Required advanced degree with minimum 10-15 years of industry experience
  • At least 10-15 years equivalent multi-/ cross-functional leadership experience in late-stage development and commercialization of products
  • Advanced level of science and clinical acumen. Experience working in genetic, rare diseases preferred
  • Cross-functional team and relationship enhancing skills
  • Previous work and leadership experience in international and multidisciplinary drug development teams and broad operational experience with an experienced understanding of drug development process
  • In-depth knowledge of preclinical, clinical, regulatory, and commercial functions, as well as business strategy and business requirements
  • Outstanding Project Management skills, including expertise in designing, developing, and managing project schedules and resource management
  • Understands financial aspects, including knowledge of resource planning (headcount and budget) and management
  • Ability to critically and objective interpret and evaluate scientific and competitive, business related information.
  • Exercise wide latitude in determining objectives and approaches critical to program/organization; requires minimal program strategic direction needed from Vice President
  • Must possess solid leadership skills
  • Strong interpersonal, communication, and negotiation skills for bridging between scientific and business participants, for negotiating timelines and for effective collaboration, with internal and external executive-level management
  • Strong verbal communication. Expert in written communications

Full Time employees across the globe enjoy a range of benefits, including, but not limited to:

Generous vacation time and public holidays observed by the company

Volunteer days

Long term incentive and Employee stock purchase plans or equivalent offerings

Employee wellbeing benefits

Fitness reimbursement

Tuition sponsoring

Professional development plans

* Benefits vary by region and country

Ultragenyx Pharmaceutical is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital and veteran status. Reasonable accommodation will be provided for qualified individuals with disabilities and for qualified disabled veterans in job application procedures, as required by applicable law.

Note to External Recruiters: All candidate activity and open positions are managed strictly through our Human Resources Department. Our Human Resources Department kindly requests that recruiters not contact employees/hiring managers directly in an attempt to solicit business and present candidates. Please note that failure to comply with this request will be a factor in determining a professional relationship with our organization. Submission of unsolicited resumes prior to an agreement set in place between the Human Resources Department and the recruiting agency will not create any implied obligation.